probability of cancer According to a recent study, the spread of metastases can be reduced by 72% thanks to aerobic exercise. According to the researchers, the amount of glucose (sugar) consumed by internal organs increases during intense aerobic exercise, reducing the amount of energy available to the tumour. (Also read: Popular dietary supplements may cause cancer: Study)
The study was led by two researchers from TAU’s Sackler Faculty of Medicine: Professor Carmit Levy from the Department of Human Genetics and Biochemistry and Dr Yftach Gepner from the Sylvan Adams School of Public Health and Sports Institute. Professor Levy emphasized that by combining scientific know-how from different schools at TAU, the new research has led to a very important discovery that could help prevent cancer from spreading – the leading cause of death. head in Israel. The article was published in the prestigious journal Cancer Research and was selected as the cover for the November 2022 issue.
Professor Levy and Dr. Gepner: “Studies have demonstrated that exercise reduces the risk of certain types of cancer by up to 35%. This positive effect is similar to that of exercise on other diseases, such as heart disease and diabetes.In this study, we added new knowledge, showing that high-intensity aerobic exercise, which derives energy from sugar, can reduce up to 72% risk of cancer metastasis. active, healthy’, we can now explain how aerobic activity can maximize the prevention of the most metastatic and malignant cancers. “
The study combined an animal model in which rats were trained to follow a rigorous exercise regimen, with data from healthy volunteers examined before and after running. Human data, obtained from an epidemiological study that followed 3,000 individuals for about 20 years, showed 72% less cancer metastasized in participants who reported regular aerobic activity at a moderate intensity. higher, compared with those who did not engage in exercise.
Animal models showed similar results, allowing the researchers to determine its underlying mechanism. Taking samples of the internal organs of healthy animals, before and after exercise, as well as after cancer injection, they found that aerobic activity significantly reduced the growth of metastatic tumors. in lymph nodes, lungs, and liver. The researchers hypothesized that in both humans and model animals, this favorable outcome was related to the increased rate of glucose consumption due to exercise.
Professor Levy: “Our study is the first to investigate the effects of exercise on internal organs that often develop metastases, such as the lungs, liver and lymph nodes. cells of these organs, we found that the cell numbers of these organs increased to glucose receptors during intense aerobic activity – increasing glucose uptake and turning organs into energy consuming machinery effective, very muscle-like. We think this happens because the organs have to compete for sugar with muscle, which is known to burn a lot. So if cancer does develop, the competition is fierce. with glucose will reduce the ability to provide energy that is important for metastasis.
Moreover, when a person exercises regularly, this condition becomes permanent: the tissue of internal organs changes and becomes similar to muscle tissue. We all know that sport and exercise are good for our health. Our study, which examined internal organs, found that exercise changes the whole body, making it impossible for cancer to spread and the primary tumor to shrink in size as well.”
Dr. Gepner added: “Our results indicate that unlike relatively moderate fat-burning exercise, it is high-intensity aerobic activity that helps prevent cancer. If the intensity range is optimal, for fat burning to be 65-70% maximum pulse rate, sugar burning requires 80-85 percent – even if only for short periods of time.
For example, sprint one minute, then walk, then another sprint. In the past, such intervals were mostly typical in athletes’ training regimens, but today we also see them in other training routines, such as cardiac rehabilitation. and lungs.
Our results suggest that healthy individuals should also include high-intensity components in their fitness program. We believe future studies will allow personalized medicine to prevent specific cancers, with doctors looking at family history to recommend the right type of physical activity. It must be emphasized that exercise, with its unique metabolic and physiological effects, represents a higher level of cancer prevention than any drug or medical intervention to date.”
This story has been published from the electronic agency’s feed without any modification to the text. Only the title has been changed.
