The Grayson-Jockey Club Research Foundation’s board of directors announced on February 13 that it has authorized $1,498,077 to fund 12 new and 9 ongoing projects at 13 schools. college as well as two career development awards. The 2023 Research List brings Grayson’s total since 1983 to more than $34.1 million to work on 426 projects at 45 universities.
“The Grayson Foundation is dedicated to addressing a variety of equine health challenges, which is clearly reflected in our selected projects for this year,” said Jamie Haydon, president of Grayson. “Our research projects and career development awards would not be possible without the kindness of our sponsors and we thank them for their understanding of the importance of our research. Veterinary care about horses.”
Here is the alphabetical list by field of new projects:
Transcriptional response to osteoarthritis
Lynn Pezzanite, Colorado State University
This study will highlight the role of cells of the immune system in contributing to the progression of osteoarthritis with the goal of developing treatments for each stage of the disease.
Efficacy of recombinant equine lubrication on osteoarthritis
Heidi Reesink, Cornell University
This study will evaluate the effectiveness of recombinant equine lubricant (rEqLub) in mitigating equine joint disease and identify the gene and protein pathways affected by rEqLub in equine joints.
Treatment of meniscus damage with mesenchymal stem cells
Aimee Colbath, Cornell University
This study will determine whether joint mesenchymal stem cells lead to improved meningeal wound healing, with immediate impact on how veterinarians treat meningiomas. brain in horses.
Neotissue stem cell transplant to cure horse tendon disease
Mandi J. Lopez, Louisiana State University
This study will determine whether a viable new tissue implant made from stem cells enhances current therapies for the treatment of debilitating tendon injuries in equestrians and companions. Are not.
Gallium Nitrate for the treatment of bacterial endometritis in mares
Dale Kelley, Oklahoma State University
This study proposes the development of new, safe and effective antibiotic strategies for the treatment of antibiotic resistance.
VapA mRNA vaccine for pneumonia R. Equi
Noah Cohen, Texas A&M AgriLife Research
This grant evaluates an mRNA vaccine administered intramuscularly to foals to protect against pneumonia caused by the bacterium Rhodococcus Equi, a major cause of morbidity and mortality in foals worldwide.
The Genome of Purebred Stallion’s Fertility
Terje Raudsepp, Texas A&M University
This project aimed to identify candidate genes and regulatory variants that impair acrosome response and low fertility in purebred stallions using cross-platform genomics.
Validation of biomarkers for neurodegeneration in horses
Carrie J. Finno, University of California Davis
It is expected that this study will improve the diagnosis of spinal cord disease in horses.
PET MRI Sports Horse Buckle
Mathieu Sriet, University of California Davis
This study will compare 18F-NaF positron emission tomography (PET) with magnetic resonance imaging (MRI) to evaluate foot lock injuries in sport horses.
The effect of antibiotics on the microbiota and resistance of the uterus
Igor Canisso, University of Illinois
This is a study of the microbiota and intrauterine microbiota of resistant and endometritis-prone mares treated with antibiotics after mating.
Nanoparticle vaccine for equine Rotavirus B
Feng Li, University of Kentucky
The vaccine candidate developed from this project will help the equine industry to control and prevent rotavirus B infection in horses.
An effective EPM vaccine is being developed
Sharon Witonsky, Virginia-Maryland CVM
This study plans to identify potential MHC class I CD8 and MHC class II CD4 protective epitopes for an effective vaccine against Sarcocystis Neurona.
Career Development Award
The Storm Cat Career Development Award, inaugurated in 2006, grants $20,000 to an individual considering a career in equine research. This year, Grayson presented the award to Dr. Shun “Shune” Kimura of the University of Georgia. Dr. Kimura’s study will investigate how immune and metabolic responses in systemic inflammatory response syndrome (SIRS) influence disease severity and determine whether metformin has anti-inflammatory effects. inflammation and metabolism are beneficial in equine SIRS.
The Elaine and Bertram Klein Career Development Award was first awarded in 2015 and grants $20,000 to a prospective equine researcher. This year’s recipient is Dr. Bethanie Cooper of North Carolina State University. Dr. Cooper’s study, entitled “Myristoylated Alanine Rich C-Kinase Substrate (MARCKS) Protein as Targeted Treatment in equine asthma,” will look at this novel protein-based therapy as a treatment. potential for horses with equine asthma.
“Grayson’s track record of career development awards in supporting developing equine researchers is undeniable, and we are delighted to extend the grants to two deserving recipients. worthy this year,” said Dr. Johnny Mac Smith, who serves as an advisor to the award. research advisory committee and is A. Gary Lavin Chairman of the foundation.
Details of the new projects are available at the following link: greyson-jockeyclub.org/default.asp?section=2&area=Research&menu=2.
The Grayson-Jockey Club Research Fund has traditionally been the nation’s leading source of equine research funding. Projects it supports promoting the health and safety of horses of all breeds. Additional information about the platform is available at greyson.jockeyclub.org.
This press release has been edited by BloodHorse Staff for content and style.
